A New, Fast and Easy Strategy for one-pot synthesis of substituted 6-amino[2,3-c] pyrazolidines as potentialNon-Steroidal Anti-inflammatory Drugs (NSAIDs)

Non Steroidal Anti-Inflammatory Drugs(NSAIDs) have been commonly used in both human andveterinary medicine to reduce pain, fever and inflammation. According to this subject synthesis of new medicinesbased on 3,5-pyrazolidine-dione(phenyl Butazone) are very important for medicinal chemists. In this work a new,easy and fast method for one-pot synthesis of substituted 6-amino[2,3,c] pyrazolidines has been developed.1,2-diphenylpyrazolidine 3,5-diones react with aromatic aldehydes and malononitrile in the presence of an organicbase affording tetra hydropyrano[2,3,c] pyrazole structures. The Structures elucidations were characterized by 1HNMR,13C-NMR and FT-IR. The mechanism of the formation has also been discussed.

کلیدواژه ها:

Non-Steroidal Anti-Inflammatory Drugs ، 3 ، 5-pyrazolidine-dione ، New and Easy strategy ، Aromaticaldehydes ، synthesis